EAGLE is an alignment-free method and associated program to compute relative absent words (RAW) in genomic sequences using a reference sequence. Currently, EAGLE runs on a command line linux environment, building an image with patterns reporting the absent words regions (in SVG) as well as reporting the associated positions into a file. EAGLE has got scripts to run on the current outbreak and the other existing ebola virus genomes (using the human as a reference), including the download, filtering and processing of the entire data.

Citation:

Raquel M. Silva, Diogo Pratas, Luísa Castro, Armando J. Pinho & Paulo J. S. G. Ferreira. Bioinformatics (2015): btv189.
DOI: 10.1093/bioinformatics/btv189.