A multi-step approach including models’ construction (multiple sequence alignment, homology modeling), complex assembling (protein complex refinement with HADDOCK and complex equilibration), and protein-protein interface (PPI) characterization (including both structural and dynamics analysis) were performed. Our database can be easily applied to several GPCR sub-families, to determine the key structural and dynamical determinants involved in GPCR coupling selectivity.

Responsible contact
irina.moreira@cnc.uc.pt; martinsgomes@gmail.com

Responsible organization

Decoding Partner Specificity of Opioid Receptor Family Barreto C.A.V. Baptista S.J. Preto A.J. Silverio D. Melo R. Moreira I.S.Frontiers in Molecular Biosciences, 2021Understanding the Binding Specificity of G-Protein Coupled Receptors toward G-Proteins and Arrestins: Application to the Dopamine Rec